Diffusely positive for both squamous and neuroendocrine markers. SMARCB1-deficient sinonasal carcinoma •Rare, high grade aggressive...

•Diagnosis: Langerhans cell histiocytosis •Majority of cases have MAPK pathway gene mutations, with BRAFp.V600E being the most prevalent.

•Diagnosis: epithelioid hemangioendothelioma (EHE) •Great variability in clinical behavior and prognosis, occurs in patients of wide age...

•Focal positivity for cytokeratin, brachyury, S100, SMA •INI1/SMARCB1 loss on immunohistochemical stain as well as SMARCB1 deletion on...

•Diagnosis: chordoma •Clinical: most commonly presents as lytic, destructive bone lesion in the axial skeleton: base of the skull, spine,...

•Diagnosis: high grade follicular cell-derived non-anaplastic thyroid carcinoma, aka: poorly differentiated thyroid carcinoma •In the...

•Diagnosis: extraosseous/peripheral ameloblastoma •10% of all amelob;astomas, occur in wide age range 9-92 •Molecular changes: similar to...

•Diagnosis: Medullary carcinoma of thyroid •2% of thyroid malignancies, and 8% of thyroid cancer-related deaths •25% of MTCs are...